Controlled Delivery of Proteins and Growth Factors

While the therapeutic protein market is already large and growing, the development of delivery platforms that are capable of targeting specific tissue sites with tailored dosing profiles is lagging significantly. Current magnetically triggered release systems are designed for use with small-molecule drugs rather than large biomacromolecules such as proteins, growth factors, and peptides. Blackfish has developed the first particle delivery system of its kind capable of the delivery of large therapeutic molecules, such as proteins, growth factors, and peptides (including GLP-1), to specific repair sites in the body.

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These microparticles can be loaded with therapeutic proteins, either a single protein or multiple, synergistic protein complexes. The particles are then injected into the tissue repair site and exposed to radiofrequency electromagnetic fields. The coupling of the electromagnetic fields to the iron oxide component transfers energy to the matrix, resulting in a partial breakdown of the polymer structure and increased diffusion of the therapeutic proteins out of the matrix and into the target tissue. Once the field is turned off, the particle re-solidifies, trapping any proteins that remain and enabling the delivery of multiple, timed therapeutic doses tailored to the healing profile of the target tissue. This system is unique in its ability to deliver multiple, tailored doses to specific repair sites with on/off remote control.